NAD Pills vs IV

More and more people are including NAD—a coenzyme indispensable for the basic functions of the human body—into their dietary supplement regime. But is taking NAD pills the best way to boost its levels? Or should you turn to IV therapy for replenishing your NAD supplies? In the article below, we discuss the pros and cons of the two methods. 

What Is NAD?

Nicotinamide adenine dinucleotide (NAD) is a coenzyme that plays a crucial role in many essential biological processes in the body, from supporting healthy cell growth to reversing DNA damage, maintaining muscle function, and promoting a healthier sleep cycle. As a powerful antioxidant, it can also slow down the aging process.


NAD is naturally produced by the body, but its levels gradually decrease with age. This decline can be further accelerated by stress, overeating, poor sleep, and the use of drugs or alcohol. Low levels of NAD can cause a range of health issues, such as diabetes, Alzheimer’s disease, and heart disease.

Benefits of NAD

Maintaining muscle tone and function

NAD is indispensable for muscle development. It provides energy to the muscle cells, ensuring increased strength and endurance. NAD supplementation is effectively used to enhance athletic performance, accelerate muscle recovery, and reduce muscle soreness after a workout.

Aiding healthy cell growth

NAD plays an essential role in cellular respiration. It is used by all types of cells in the body to generate cellular energy and ensure healthy cell growth. 

Counteracting cellular damage

Following brain injury or neurodegenerative disease, the mitochondria release free radicals that may cause further damage to the cells. Boosting NAD levels has been shown to reduce cellular damage due to free radical buildup.

Reversing the damage done to the mitochondria

NAD can repair the damage in the mitochondria caused by a range of genetic and environmental factors like pollution, radiation from sunlight and radon, and industrial chemicals. It also enables the brain to function at the optimal level by repairing and reinforcing the activity of neurons and protecting them from further damage

Slowing down aging

One of the most important benefits of NAD is countering the effects of aging. NAD deficiency is associated with signs of aging like chronic fatigue, depression, stress and anxiety, weakened immune system, sleep issues, memory problems, and more. Increasing NAD levels through supplementation can repair the damage caused by the reduced functioning of the molecule. Moreover, NAD is the key to reversing the dermal signs of aging, for example, the appearance of fine lines and wrinkles, the loss of skin elasticity, and photoaging due to long-term sun exposure.

Combating age-related diseases

Research has confirmed a direct correlation between NAD levels and cardiovascular and metabolic age-related diseases, including Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, fibromyalgia, and diabetes. Replenishing NAD levels via supplements has beneficial effects when it comes to combating these diseases.

Improving metabolism

NAD acts as a delivery mechanism in energy creation during metabolic chemical reactions that occur in the body. It plays an important role in the body’s metabolic regulation and energy homeostasis, a balance of the production and consumption of metabolic resources. If your body has adequate levels of NAD and your metabolism is functioning properly, your energy levels will be high. Because boosting metabolism is key to keeping weight under control, increasing NAD levels can also help lose weight.

Setting your body’s circadian rhythm

NAD regulates your body's internal clock, known as the circadian rhythm. If your circadian rhythm is not functioning properly, your sleeping patterns will get disrupted, potentially leading to various health issues, accelerating the aging process, and making you more prone to disease. Taking NAD supplements can help normalize your circadian rhythm and improve your sleep quality.

Pros of NAD Supplements

  • NAD supplements that are taken orally are readily available from local convenience stores and online retailers. 
  • NAD pills are convenient and can be taken at any time.
  • No equipment is required for taking NAD supplements.
  • For immunocompromised individuals, taking NAD pills is safer than IV therapy since it limits exposure to intravenous care and minimizes the risk of infections. 
  • NAD supplements are affordable, with a price starting at $30.

Cons of NAD Supplements

  • The digestive system partially breaks down the nutrients before the cells get a chance to fully absorb NAD supplements. This makes them less effective than intravenous therapy.
  • The effectiveness of NAD supplements varies from person to person. It may depend on the factors such as your circulatory system and your body’s response to the supplement.
  • There are risks involved in taking high quantities of store-bought supplements as they often contain artificial ingredients.

Pros of NAD IV

  • NAD IV therapy is highly effective. It delivers NAD directly into your bloodstream, making it immediately available for your cells with a 100% absorption rate.
  • Unlike store-bought oral supplements, the NAD IV solution contains no artificial ingredients. IV treatment is a holistic therapy that uses only naturally occurring chemicals, so that no synthetic or harmful substances will enter your body. 
  • NAD IV therapy has immediate effects and offers lasting results.
  • Getting NAD via intravenous infusion offers many additional benefits. IV formulas are typically based on a normal saline solution that rehydrates your body and flushes out any toxins or free radicals. 
  • An IV formula can include other vitamins and minerals that your body needs. Adding these essential nutrients to the IV solution will not only enhance the effectiveness of NAD, but also allow you to enjoy additional benefits such as increased energy, mental clarity, improved cognitive function, and overall well-being.
  • NAD IV therapy is a safe treatment with very rare and mild side effects like nausea, fatigue, and headache

Cons of NAD IV

  • NAD IV therapy takes longer than simply swallowing a NAD pill. Depending on the type of your treatment, a session can last anywhere from 1.5 to 4 hours. 
  • IV therapy must be administered by a certified nurse and requires special equipment, including IV poll, catheter, and other supplies.
IV treatments are expensive, with prices starting at $200.